Acetaminophen Production in Global Healthcare Acetaminophen (APAP), also known as paracetamol, is one of the most widely used analgesics and antipyretic drugs worldwide. It was first synthesized in the 19th century (initially reported by Charles Gerhardt in 1852 and later by Harmon Northrop Morse in 1878). It became commercially important in the 20th century as a safer alternative to Aspirin. Today, Acetaminophen is listed on the WHO Model List of